Loss of Immune-Regulating Protein Eases Alzheimer’s Disease, Research By Kyoto University Finds
The loss of a certain immune-regulating protein in the brain leads to a decrease in the levels of amyloid beta, which causes Alzheimer’s disease, and improves cognitive function, a group of researchers including from Kyoto University has found. The group confirmed that the TIM-3 protein, which exists in microglia, a type of immune cell in the brain, increases as the brain ages. When it removed the protein from a mouse with Alzheimer’s disease by genetic modification, the accumulation of amyloid beta decreased by 50 to 60 pct, and the mouse showed an improvement in cognitive function.



